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Clopidogrel is inactive when administered It must be metabolized in the liver (mainly by CYP2C19) into an active thiol metabolite The active metabolite then produces the antiplatelet effect Mechanism of action The active metabolite irreversibly inhibits the P2Y ADP receptor on platelets This prevents platelet activation and aggregation Clinical uses Prevention of ischemic stroke Prevention of myocardial infarction Postcoronary stent placement Alternative to aspirin in aspirin intolerance Delayed onset compared to aspirin (because activation is required) Reduced efficacy in patients with CYP2C19 deficiency or when taken with CYP2C19 inhibitors (e.g., omeprazole) Effect lasts for the life of the platelet (710 days) Clopidogrel = Prodrug Aspirin = Active drug Prasugrel, Ticagrelor antiplatelets (note: ticagrelor is NOT a prodrug) To view or add a comment, sign in With respect to gliptins and Parkinson's disease, which statement is false
So when you draw 40 units, you are drawing 40/100 of a milliliter, which equals 0.4 mL
This was a landmark moment because it represented global recognition of GLP-1 medications as a legitimate long-term treatment for obesity rather than a temporary or supplementary intervention
Although doctors consider the lipase test the best one to diagnose acute pancreatitis, your doctor may also order a blood test for amylase, another enzyme that rises when there's a problem with your pancreas
